Eurofever Project

This Project was promoted by the Autoinflammatory Diseases’ Working Group of the Paediatric Rheumatology European Society (PRES) and is supported by the Executive Agency for Health and Consumers (EAHC, Project No2007332,

The general aims of the Eurofever project are to:  

  • sensitize pediatricians and pediatric rheumatologists to the prompt recognition of Autoinflammatory Diseases;
  • provide proper information to families affected by these conditions
  • increase the knowledge on the clinical presentation, response to treatment and complications of theses rare disorders. 

The Eurofever project includes the following actions: 

  • a survey on the prevalence of diagnosed or suspected autoinflammatory diseases among all European Paediatric Rheumatology Centers
  • an international Registry for Autoinflammatory diseases
  • a survey on the efficacy of treatment in these disorders
  • elaboration of outcome measures for possible future therapeutic trials
  • informative webpages for patients and physicians on each disorder

The following conditions are considered by the Project:

  • Behçet disease
  • Blau’s syndrome/Early onset sarcoidosis
  • Cryopyrin associated periodic syndrome
  • Chronic recurrent multifocal osteomyelitis
  • Deficiency of IL-1 receptor antagonist
  • Familial Mediterrean Fever
  • Mevalonate kinase deficency (Hyper IgD syndrome)
  • NLRP12 -associated periodic syndrome
  • Pyogenic Sterile Arthritis, Pyoderma Gangrenosum and Acne (PAPA) syndrome
  • Tumor necrosis factor receptor-associated periodic syndrome (TRAPS)
  • Periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA)
  • CANDLE syndrome
  • DITRA syndrome
  • Schnitzler syndrome
  • Sindrome di Majeed
  • Undefined Periodic fever

The Project is originally addressed to the Centres referring  to the PRES/PRINTO network, but is  also open to a direct functional integration to other already existent initiatives involving also adult patients, such as Eurotraps Project ( and the Hyper-IgD registry (

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